Our group focuses on the design, construction, and application of DNA and RNA nanostructures and nanodevices. Utilizing Watson-Crick base pairing, we fold DNA and RNA into custom forms through self-assembly. We engineer 2D and 3D nanostructures that can be programmed for controlled movement and conformational changes. We interface DNA nanostructures with various functional materials, including small organic molecules, peptides, polymers, and inorganic materials. Our DNA and RNA nanostructures have broad applications, spanning biosensing, drug delivery, bioimaging, and molecular computing.